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Inhibitors for JAK/STAT Signaling [AG Scientific] 바이오클론 2014.11.27
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Inhibitors for JAK/STAT Signaling

 

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.


Products


NameCAS No.Cat No. 
CP-690550 477600-75-2C-2271A Janus Kinase 3 (JAK3) inhibitor
CRT Inhibitor, ICRT5  C-2273A potent inhibitor of the β-catenin-responsive transcription (CRT) in the nucleus
Dorsomorphin
(Compound C)
866405-64-3D-1310a cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase in an ATP-competitive manner
Lestaurtinib111358-88-4L-2374Acts as a potent inhibitor of several tyrosine kinases including FLT3, JAK2, and TrkA 
MS-1020  M-2357A selective JAK3 inhibitor
PP2 172889-27-9P-1103An inhibitor of the Src family of kinases.
TAK 165 366017-09-6T-2450A potent inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase 
Tyrphostin, AG 490 133550-30-8A-1164AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase
WHI-P131 202475-60-3W-2482Selectively inhibits the tyrosine kinase activity of Jak3
WP1066 857064-38-1W-2483A potent JAK2 inhibitor
PATHWAYREADY™ JAK/STAT Signaling Inhibitor Panel P-2382eight inhibitors useful for studying JAK/STAT signaling pathway
5 mg AG 490,
5 mg CP-690550,
500 ?g Lestaurtinib,
5 mg LLL12,
50 mg Pimozide,
5 mg Stat3 Inhibitor, S3I-201,
5 mg Stat3 Inhibitor, Celll-Permeable,
5 mg WP1066



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