|
| New Products
|
| April
2015 |
 Selective allosteric
inhibitor of IKK |
| 4806 | BMS 345541 |
| IC50 values are 0.3 and 4.0 μM for IKKβ and IKKα respectively. Exhibits no effect against a panel of 15 other
kinases. Attenuates LPS-induced cytokine production in vitro and blocks
NFκB dependent transcription in mice. Also suppresses
joint destruction in a mouse model of arthritis. |
| Related Products: IKK 16 ACHP ML 120B |
 |
| Potent and selective
GlyT1 inhibitor |
| 5308 | ASP 2535 |
| IC50 = 92 nM. Exhibits 50-fold selectivity over
GlyT2. Attenuates MK 801-induced working memory deficits and PCP -induced visual learning deficits in mice. Orally
available and brain penetrant. |
| Related Products: ALX 5407 LY 2365109 Org 24598 |
|
| Potent allosteric
inhibitor of PRMT3 |
| 5367 | SGC 707 |
| IC50 = 31 nM. Inhibits PRMT3-mediated
methyltransferase activity in vitro. Displays >100-fold selectivity
against 31 other methyltransferases and 250 other non-epigenetic targets.
|
| Related Products: TC-E 5003 C 21 XY1 |
|
| Potent and selective
Lck and Src inhibitor |
| 5413 | WH-4-023 |
| IC50 values are 2 and 6 nM for Lck and Src
respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3
respectively) and displays selectivity over a range of closely related kinases.
Supports self-renewal of naive hESCs in combination with PD 0325901, CHIR 99021 and SB 590885. |
| Related Products: TC-S 7003 Src I1 A 419259 |
|
| ATP
non-competitive kinesin Eg5 inhibitor |
| 5454 | BRD 9876 |
| ATP non-competitive
kinesin Eg5 inhibitor. Selectively inhibits microtubule-bound Eg5. Inhibits
multiple myeloma cell growth (IC50 = 2.2
μM). |
| Related Products: Monastrol K 858 Dimethylenastron |
|
| All new products this month |
| A12B4C3, APcK 110 ASP 2535, BDY 630-X, SE BDY 650-X, SE BDY FL, SE BDY TMR-X, SE BDY TR-X, SE BIX BMH 21 BMS 345541, BRD 9876, BTC, Elinogrel, FFN 102 mesylate, FITC GW 438014A, Heclin, Norleual, OXA 06, PACMA 31, PCI 29732, Ractopamine, Rhosin, Ro 48-8071, SEN 1269, SGC 707, Sulforhodamine 101 acid chloride T2AA TC-S 7006, WH-4-023, XY1 |
|
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Tocris Bioscience. All Rights Reserved. |
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