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| New Products |
| March 2015 |
 Potent and selective DGAT-1 inhibitor |
| 4837 | AZD 3988 |
| IC50 = 0.6 nM. Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable. |
| Related Products: CI 976 A 922500 (R)-(+)-Etomoxir sodium salt |
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| Selective Mps1 kinase inhibitor |
| 5142 | Mps1-IN-1 |
| IC50 = 367 nM. Exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells. |
| Related Products: AZ 3146 TC-S 7005 TC Mps1 12 |
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| Potent and selective BRPF1 inhibitor |
| 5385 | GSK 5959 |
| IC50 = 80 nM. Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3. Cell permeable. |
| Related Products: (+)-JQ1 I-BET 151 SGC-CBP30 |
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| Aquaporin 1 (AQP1) channel blocker |
| 5412 | TC AQP1 1 |
| IC50 = 8 μM. Inhibits water flux in Xenopus oocytes. |
| Related Products: ω -Conotoxin GVIA SNX 482 TGN 020 |
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| Inhibitor of TNFα receptor 1 signaling |
| 5432 | R 7050 |
| Blocks TNFαR1 association with TRADD and RIP1. Inhibits TNFα-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice. |
| Related Products: SB 431542 YM 90709 AF 12198 |
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| All new products this month |
| 3PO, 4BP-TQS, A 85380, A01, ACT 462206, AEE 788, ARN 272, AZD 3988, Benzbromarone, BTB1, Cariporide, CKI 7, Clemizole, CX 614, Gap19, GSK 5959, IWP 12, IWP 4, JJKK 048, JNJ 47965567, D-Luciferin sodium salt, M8 B, ML 240, ML 297, ML 349, Mps1-IN-1 dihydrochloride, MRS 5698, Pregnenolone sulfate sodium salt, R 268712, R 7050, T 5601640, TC AQP1 1, TC-FPR 43, TC-S 7009, TG 4-155, TGN 020, UNC 2400, Verteporfin, WDR5 0103, XL 184 |
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