bs-2347R

Rabbit Anti-GP1B Polyclonal Antibody

Antibody Type

Polyclonal

Host

Rabbit

Isotype

IgG

Reactivity

Human,Mouse,Rat

Concentration

1ug/ul

Application

WB, ELISA, FCM, IHC-P, IF(IHC-P)

Background

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq, Mar 2010].

Additional Information

Conjugation

Unconjugated

Target Protein

GP1B/CD42b

Gene ID

Entrez Gene: 2811

Source

KLH conjugated synthetic peptide derived from human GP1B

Purification

Purified by Protein A.

Storage Condition

Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

Synonym

Platelet glycoprotein Ib alpha chain; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b-alpha; GP1BA

Publication

Ye, Buqing, et al. "Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation." The Journal of Experimental Medicine (2014): jem-20141123. Read more>>