Inhibitors for JAK/STAT Signaling
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
| Name | CAS No. | Cat No. | | | CP-690550 | 477600-75-2 | C-2271 | A Janus Kinase 3 (JAK3) inhibitor | | CRT Inhibitor, ICRT5 | | C-2273 | A potent inhibitor of the β-catenin-responsive transcription (CRT) in the nucleus | Dorsomorphin
(Compound C) | 866405-64-3 | D-1310 | a cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase in an ATP-competitive manner | | Lestaurtinib | 111358-88-4 | L-2374 | Acts as a potent inhibitor of several tyrosine kinases including FLT3, JAK2, and TrkA | | MS-1020 | | M-2357 | A selective JAK3 inhibitor | | PP2 | 172889-27-9 | P-1103 | An inhibitor of the Src family of kinases. | | TAK 165 | 366017-09-6 | T-2450 | A potent inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase | | Tyrphostin, AG 490 | 133550-30-8 | A-1164 | AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase | | WHI-P131 | 202475-60-3 | W-2482 | Selectively inhibits the tyrosine kinase activity of Jak3 | | WP1066 | 857064-38-1 | W-2483 | A potent JAK2 inhibitor | | PATHWAYREADY™ JAK/STAT Signaling Inhibitor Panel | | P-2382 | eight inhibitors useful for studying JAK/STAT signaling pathway
5 mg AG 490,
5 mg CP-690550,
500 ?g Lestaurtinib,
5 mg LLL12,
50 mg Pimozide,
5 mg Stat3 Inhibitor, S3I-201,
5 mg Stat3 Inhibitor, Celll-Permeable,
5 mg WP1066 |
ISO 9001:2008 인증제조 업체 A.G. scienticfic사는 High Quality 시약을 공급합니다. ★ Small size, Bulk size 공급가능. 기타 Products 는 www.agscientific.com을 참조 하세요.
금요일 5시 발주
자세한 문의는 바이오클론으로 연락 주세요
TEL : 02-2690-0058
email : bioclone@bioclone.co.kr |
